|About the Book|
Recognized authorities in their respective areas provide contemporary information on insulin resistance. Organized into 12 chapters covering a broad range of subjects pertaining to insulin action, mechanisms of insulin resistance and clinicalMoreRecognized authorities in their respective areas provide contemporary information on insulin resistance. Organized into 12 chapters covering a broad range of subjects pertaining to insulin action, mechanisms of insulin resistance and clinical consequences, this book integrates and unites recent advances which have occurred in several disparate fields. The role of defects in the glucose transport system and future approaches to specific treatment of insulin resistance are among the topics discussed.An overview of insulin resistance / J.S. Flier --Mechanisms of insulin action / M.F. White and C.R. Kahn --Syndromes of severe insulin resistance: clinical and pathophysiological features / D.E. Moller and S. ORahilly --Mutations of the insulin receptor gene / S.I. Taylor and D.E. Moller --Autoimmune mechanisms of insulin resistance and hypoglycemia / P. Gorden, P. Roach and E. Collier --Insulin resistance and its role in the pathogenesis of impaired glucose tolerance and non-insulin-dependent diabetes mellitus: perspectives gained from in vivo studies / A. Alzaid and R.A. Rizza --Potential cellular and genetic mechanisms for insulin resistance in the common disorders of diabetes and obesity / B.L. Seely and J.M. Olefsky --Cellular defects in glucose transport: lessons from animal models and implications for human insulin resistance / P.R. Shepherd and B.B. Kahn --Insulin resistance and ovarian dysfunction / A. Dunaif --Insulin resistance in hypertension / U. Smith --Insulin resistance, hyperinsulinemia, dyslipidemia and atherosclerosis / R.W. Stout. (cont) Therapeutic approaches to insulin resistance / A.C. Moses and M.J. Abrahamson.